MAIN MENUScientists have successfully slowed down the process of aging; Anti-aging drug will hit the market in 2-3 years
Russian and Swedish scientists have reported a major
breakthrough in slowing down the process of aging. The
goal of the study is to know the role of mitochondria in
the process of aging of the organism. They made an
attempt to slow down aging by introducing an artificial
antioxidant SkQ1 into mitochondria.
- Russian biologist professor Vladimir Skulachev prepared the
artificial antioxidant SkQ1. - Experiments were carried on
genetically modified mice developed and characterized
in Sweden
- Scientists introduced a single mutation into the genome
of mice, as a result, there was accelerated mutagenesis in
mitochondria. This leads to accelerated aging and early
death of mutant mice.
- Researchers chose two groups of mutant mice aged 100
days for the study. To one group they gave water added
with artificial antioxidant (12 micrograms). The second group
was kept as control and fed with pure water
- There was a clear difference in aging of the two groups
of mice from 200-250 days . As expected the control
mice aged rapidly and there are visible symptoms of aging
that included loss of weight, raising body temperature, the
curvature of the spine and there was even the impairment
of estrous cycle in females.
- On the other hand, there was a decrease in the appearance
of age-related traits in mice treated with antioxidant SkQ1,
In some mice, aging traits did not appear at all in the
group.
Professor Vladimir Skulachev, Co-author of the study said
that the study helps to know the role of mitochondria in the aging process and also opens the way for the treatment of aging by using mitochondria targeted antioxidants. Researchers are now developing a set of pharmaceutical products based on antioxidant SkQ1.
Their first drug - Visomitin eye drops - is already approved
and marketed in Russia, it also passed phase 2 clinical trials in the US. Next on they are now working on an oral form of SkQ1 which is currently in clinical trials. The antiaging drug may be approved and hit the market for systemic indications in 2-3 years.
breakthrough in slowing down the process of aging. The
goal of the study is to know the role of mitochondria in
the process of aging of the organism. They made an
attempt to slow down aging by introducing an artificial
antioxidant SkQ1 into mitochondria.
- Russian biologist professor Vladimir Skulachev prepared the
artificial antioxidant SkQ1. - Experiments were carried on
genetically modified mice developed and characterized
in Sweden
- Scientists introduced a single mutation into the genome
of mice, as a result, there was accelerated mutagenesis in
mitochondria. This leads to accelerated aging and early
death of mutant mice.
- Researchers chose two groups of mutant mice aged 100
days for the study. To one group they gave water added
with artificial antioxidant (12 micrograms). The second group
was kept as control and fed with pure water
- There was a clear difference in aging of the two groups
of mice from 200-250 days . As expected the control
mice aged rapidly and there are visible symptoms of aging
that included loss of weight, raising body temperature, the
curvature of the spine and there was even the impairment
of estrous cycle in females.
- On the other hand, there was a decrease in the appearance
of age-related traits in mice treated with antioxidant SkQ1,
In some mice, aging traits did not appear at all in the
group.
Professor Vladimir Skulachev, Co-author of the study said
that the study helps to know the role of mitochondria in the aging process and also opens the way for the treatment of aging by using mitochondria targeted antioxidants. Researchers are now developing a set of pharmaceutical products based on antioxidant SkQ1.
Their first drug - Visomitin eye drops - is already approved
and marketed in Russia, it also passed phase 2 clinical trials in the US. Next on they are now working on an oral form of SkQ1 which is currently in clinical trials. The antiaging drug may be approved and hit the market for systemic indications in 2-3 years.
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